valuation of proteinuria indexes in children

Abstract

<p>The aim was to find out a reliable index for the degree of proteinuria in children by examining just a single urine sample. In this study, 49 patients with normal or reduced glomerular filtration rate and variable degrees of protein loss were studied. Urine sample were collected in separate bottles for twenty four hours. Protein concentration was measured using sulfosaliciylic acid and creatinine concentration using Jaffe method. Protein/creatinine ratio and hourly protein excretion were calculated. In each urine sample, there was a strong relation between early morning urine protein concentration and twenty-four-hour urine protein excretion in children with proteinuria, with normal or reduced glomerular filtration rate (r=0.798 and r=0.822, respectively). In patients with normal or reduced glomerular filtration rate, hourly urine protein excretion taken at different times showed different correlation with twenty-four-hour urine protein excretion and this can not be a reliable index. In patients with normal or reduced glomerular filtration rate, the early morning urine protein concentration and in the protein/creatinine ratio afternoon urine sample showed a strong correlation with twenty four hours urine protein excretion (r=0.842, r=0.923, r=0.765, r=0.930, respectively). In children with normal and reduced glomerular filtration rates; the early morning urine protein concentration, the early morning urine protein/creatinine ratio and afternoon urine protein/creatinine ratio are reliable and easily appliable indexes for the detection of the degree of proteinuria.</p>

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<p>?ocuklarda protein?ri indekslerinin de?erlendirilmesi</p>

<p>?ocuklarda protein?rinin derecesinin saptanmas?nda tek bir idrar ?rne?inin incelenmesine dayanan protein?ri indekslerinden hangisinin daha g?venilir oldu?unun saptanmas? ama?land?. ?al??maya glomerul filtrasyon h?zlar? normal veya d???k olan, tan?lar? ve idrarla at?lan protein miktarlar? geni? bir da??l?m g?steren 49 olgu (ya?lar? ortalama 7.8?3.1 y?l) al?nd?. Hastalar?n yirmi d?rt saatlik idrar? her idrar ?rne?i ayr? bir ?i?eye al?narak topland?, idrar ?rneklerinde sulfosalisilik asit y?ntemi ile protein konsantrasyonu, Jaffe y?ntemiyle kreatinin konsantrasyonu ?l??ld?. Her bir idrar ?rne?inde protein/kreatinin oran?, saatlik idrar protein miktar? hesapland?. Glomer?ler filtrasyon h?z? normal veya d???k olan protein?rili ?ocuklarda erken sabah idrar?nda protein konsantrasyonu ile g?nl?k idrar protein miktar? aras?nda ?ok g??l? bir ili?ki (s?ras?yla r= 0,798, r= 0.822) bulundu. Saatlik idrar protein miktar?n?n glomerul filtrasyon h?z? d???k ve normal olan hasta gruplar?nda g?nl?k idrar protein miktar? ile farkl? zaman dilimlerinde farkl? korelasyon g?sterdi?i saptand? ve g?venilir bir y?ntem olmad??? sonucuna var?ld?. Glomer?ler filtrasyon h?z? normal ve d???k olan hastalarda erken sabah idrar? ve ??leden sonraki idrar ?rneklerinde ?l??len protein/kreatinin oran?n?n g?nl?k idrar protein miktar? ile ?ok g??l? (s?ras?yla r= 0.842, r=0.923, r= 0.765, r= 0.930,) korelasyon g?sterdi?i saptand?. Glomerul filtrasyon h?z? normal ve d???k olan ?ocuklarda, erken sabah idrar?nda protein konsantrasyonu ve erken sabah idrar? ile ??leden sonraki idrarlardaki protein/kreatinin oran?, protein?rinin derecesi hakk?nda g?venilir bilgi veren ve kolay y?ntemlerdir.</p>