The relationship between nasal and paranasal sinus tomography findings in children with asthma and prick test, high Ig levels, eosinophylia and frequency of asthma attacks

Abstract

<p>Nasal and paranasal sinus computerized tomographies, hematologic and clinical findings have been evaluated in a group of children with bronchial asthma in order to document the prevalence of abnormal sinus tomography findings and to determine how they effect the clinical course of asthma. The frequency of asthma attacks in the previous year was 5.00?3.62 in children with allergic asthma and 3.45?2.66 in children with non allergic asthma (p=0.2221). Blood absolute eosinophil count was 891.81?502.68 in the first group and 342.18?153.94 in the second group (p=0.014). Similarly serum total Ig was 867.62?1081.10 in the allergic group and 117.67?122.99 in the non allergic group (p=0.0302). Among 21 children with allergic asthma 18 patients had abnormal nasal and paranasal sinus computerized tomography findings while only 5 patients had such pathologies in the non allergic group. There was a significant difference between the two groups in this respect (p=0.0350). We found that the children having abnormal nasal and paranasal sinus computerized tomography findings had a mean of 5.13?3.35 attacks in the previous year, while the children having no sinus pathologies had a mean of 2.22?1.48 attacks in the previous year. In children with asthma who had abnormal sinus findings, the frequency of asthma attacks was significantly higher (p=0.0184). In conclusion the higher frequency of paranasal sinus pathologies in the allergic asthma group supports the hypothesis ?one airway, one disease?. Determining the possible nasal and paranasal sinus pathologies in asthmatic children who had a poor response to optimal therapy, and treating them appropriately may help the physicians to control the disease better.</p>

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<p>Ast?ml? ?ocuklarda nazal ve paranazal sin?s tomografisi bulgular?n?n alerji deri testi, Ig y?ksekli?i, eozinofili ve atak s?kl??? ile ili?kisi</p>

<p>Bir grup ast?ml? ?ocuk hastada, anormal nazal ve paranazal sin?s tomografi bulgular?n?n s?kl??? ile, bu birlikteli?e katk?da bulunan fakt?rleri ve sin?s patolojilerinin ast?m klinik seyrine ne ?l??de etki etti?ini ortaya koymak amac?yla nazal ve paranazal sin?s tomografisi, hematolojik ve klinik bulgular de?erlendirildi. Alerjik ast?ml? olgularda son bir y?l i?indeki ast?m ata?? say?s? 5.00?3.62, nonalerjik ast?ml? ?ocuklarda 3.45?2.66 olarak tespit edildi (p=0.2221). ?lk grupta periferik kanda mutlak eozinofil say?s? 891.81?502.68, ikinci grupta 342.18?153.94 (p=0.014); yine alerjik grupta immunglobulin (Ig) d?zeyi 867.62?1081.10 ve nonalerjik olgularda 117.67?122.99 (p=0.0302) bulundu. Yirmi bir alerjik olgunun 18?inde anormal nazal ve paranazal sin?s tomografi bulgular? tespit edildi. Nonalerjik grupta ise 11 olgunun sadece 5?inde sin?s patolojisi saptand?. Gruplar aras?nda anormal sin?s tomografi bulgular?n?n s?kl??? a??s?ndan anlaml? bir fark mevcuttu (p=0.0350). ?al??maya dahil edilen ast?ml? ?ocuklarda son bir y?l i?inde ge?irilen atak say?s? ile sin?s patolojisi ili?kisi ara?t?r?ld???nda anormal sin?s bulgular? olan olgularda atak say?s? ortalamas?n?n 5.13?3.35, sin?s patolojisi olmayan olgularda ise 2.22?1.48 oldu?u tespit edildi. Anormal nazal ve paranazal sin?s tomografi bulgular? olan ast?ml?larda atak s?kl???n?n belirgin olarak y?ksek oldu?u saptand? (p=0.0184). Sonu? olarak nazal ve paranazal sin?s patolojilerinin alerjik olan ast?ml?larda daha fazla g?zleniyor olmas? ?tek havayolu, tek hastal?k? hipotezini destekler niteliktedir. Bu veriler ?????nda, optimal tedaviye yeterli yan?t al?namayan ast?ml? ?ocuklarda olas? nazal ve paranazal sin?s patolojilerini ortaya koyarak tedaviyi bu y?nde ?ekillendirmenin hastal???n gidi?i ?zerine pozitif y?nde etkili olabilece?i anla??lmaktad?r.</p>