L-asparaginase therapy and complications in children with acute lymphoblastic leukemia

Abstract

<p>Childhood acute lymphoblastic leukemia (ALL) is treated by combination chemotherapy with a number of drugs, always including the enzyme L asparaginase. Complications of this therapy include allergy, hyperglycemia, deficiency of plasma proteins, thrombotic and haemorrhagic diathesis, lipid abnormalities and pancreatitis. The paper reported here demonstrates adverse reactions in 25 children with ALL undergoing therapy with L-asparaginase and we discussed the clinical presentation, pathophysiology, and suggested treatment of the drug's adverse reactions.</p>

<hr />
<h5>Akut lenfoblastik l?semili ?ocuklarda L-asparajinaz tedavisi ve komplikasyonlar?</h5>

<p>?ocukluk ?a?? akut lenfoblastik l?semi (ALL) tedavi protokolleri daima L-asparajinaz enzimini i?eren, bir?ok ila?tan olu?an kombinasyon kemoterapisi ile tedavi edilir. Bu tedavinin komplikasyonlar? alerji, hiperglisemi, plazma proteinlerinin eksikli?i, trombotik ve hemorajik diyatez, lipit anomalileri ve pankreatiti i?erir. Bu makalede L-asparajinaz alan 25 ALL'li ?ocukta olu?an yan etkiler bildirildi ve ilac?n yan etkilerinin klini?i, patofizyolojisi ve tedavisi g?zden ge?irildi.</p>